The upcoming June international window features Nations League play, friendlies and preparations for the Qatar 2022 World Cup, which begins in under six months.
Players from MLS are expected to represent numerous teams across Concacaf and Conmebol, as well as in CAF, Oceania and UEFA.
Below is a running list of players called in for their respective national teams. It will be updated as more squads are announced.
- Ronald Hernández (D, Venezuela) - injured
- None yet
- Alan Franco (M, Ecuador)
- Kamil Jozwiak (F, Poland)
- Christian Makoun (D, Venezuela)
- Karol Swiderski (F, Poland)
- Miguel Navarro (D, Venezuela)
- Xherdan Shaqiri (M, Switzerland)
- None yet
Colorado Rapids
- Mark-Anthony Kaye (M, Canada)
- Milos Degenek (D, Australia)
- Derrick Etienne Jr. (F, Haiti)
- Jonathan Mensah (D, Ghana)
- Eloy Room (GK, Curaçao)
FC Dallas
- Paul Arriola (F, United States)
- Jesus Ferreira (F, United States)
- Nanu (D, Guinea-Bissau)
- Szabolcs Schön (F, Hungary)
D.C. United
- Michael Estrada (F, Ecuador)
- Edison Flores (M, Peru)
- Taxi Fountas (F, Greece)
Houston Dynamo FC
- Adalberto Carrasquilla (M, Panama)
- Sebastián Ferreira (F, Paraguay)
- Teenage Hadebe (D, Zimbabwe)
- Zarek Valentin (D, Puerto Rico)
- Darwin Cerén (M, El Salvador)
- Kellyn Acosta (M, United States)
- Jose Cifuentes (M, Ecuador)
- Maxime Crépeau (GK, Canada)
- Doneil Henry (D, Canada)
- Diego Palacios (D, Ecuador)
- Tomas Romero (GK, El Salvador)
- Julián Araujo (D, Mexico)
- Raheem Edwards (D, Canada)
- Kelvin Leerdam (D, Suriname)
- Rayan Raveloson (M, Madagascar)
Inter Miami CF
- Edison Azcona (M, Dominican Republic)
- Leonardo Campana (F, Ecuador)
- Joevin Jones (D/M, Trinidad & Tobago)
- Damion Lowe (D, Jamaica)
- Robert Taylor (M, Finland)
- DeAndre Yedlin (D, United States)
Minnesota United FC
- Kervin Arriaga (M, Honduras)
- Michael Boxall (D, New Zealand)
- Robin Lod (F, Finland)
- Dayne St. Clair (GK, Canada)
CF Montréal
- Ahmed Hamdi (M, Egypt)
- Alistair Johnston (D, Canada)
- Lassi Lappalainen (F, Finland)
- Djordje Mihailovic (M, United States) - injured
- Kamal Miller (D, Canada)
- Samuel Piette (M, Canada)
- Romell Quioto (F, Honduras)
Nashville SC
- Anibal Godoy (M, Panama)
- Walker Zimmerman (D, United States)
- Adam Buksa (F, Poland)
- Matt Turner (GK, United States)
New York City FC
- Alexander Callens (D, Peru)
- Maxime Chanot (D, Luxembourg)
- Sean Johnson (GK, United States)
New York Red Bulls
- Cristian Cásseres Jr. (M, Venezuela)
- Aaron Long (D, United States)
Orlando City SC
- Pedro Gallese (GK, Peru)
- Jhegson Mendez (M, Ecuador)
- Wilfredo Rivera (F, Puerto Rico)
Philadelphia Union
- Andre Blake (GK, Jamaica)
- Dániel Gazdag (M, Hungary)
- José Martínez (M, Venezuela)
- Olivier Mbaizo (D, Cameroon)
Portland Timbers
- Pablo Bonilla (D, Venezuela)
- Bill Tuiloma (D, New Zealand)
Real Salt Lake
- Rubio Rubin (F, Guatemala)
- Ousseni Bouda (F, Burkina Faso)
- Francisco Calvo (D, Costa Rica)
- Marcos López (D, Peru)
- Jamiro Monteiro (M, Cape Verde)
Seattle Sounders FC
- Xavier Arreaga (D, Ecuador)
- Jordan Morris (F, United States)
- Cristian Roldan (M, United States)
- Albert Rusnák (M, Slovakia)
- Nouhou Tolo (D, Cameroon)
Sporting Kansas City
- Marinos Tzionis (M, Cyprus)
- Daniel Salloi (F, Hungary)
Toronto FC
- Jonathan Osorio (M, Canada) - injured
Vancouver Whitecaps FC
- Janio Bikel (M, Guinea-Bissau)
- Javain Brown (D, Jamaica)
- Andres Cubas (M, Paraguay)
- Lucas Cavallini (F, Canada)